Combining CPAs to Reduce Cellular Damage During Cryopreservation
Cryoprotective agents (CPAs) are essential in the cryopreservation process, safeguarding cells from ice formation that can cause irreversible damage. However, one of the key challenges in cryopreservation is the potential toxicity of CPAs when used in high concentrations needed for effective protection. This toxicity can compromise cell viability and functionality—a significant concern in preserving cells for future use.
Innovative Solution: Combining CPAs for Reduced Toxicity
Advancements in cryopreservation techniques are leading us towards more refined solutions. One promising strategy is the combination of different CPAs to lower the overall concentration of each, reducing their toxic effects while still achieving robust cryoprotection.
A recent breakthrough involves the use of trehalose in combination with glycerol. Trehalose is a disaccharide known for its ability to protect cells in extreme conditions. When paired with glycerol, this combination has been shown to efficiently preserve both the viability and functional integrity of cryopreserved human adipose-derived stem cells.
What Does This Mean for Cryopreservation?
This approach could redefine how we think about cell preservation. By optimizing CPA formulations, we can significantly improve the outcomes of cryopreservation, making it more effective and less harmful to cells. The potential applications are vast, from biobanking to regenerative medicine, ensuring that preserved cells remain viable and functional when they are needed most.
At Consarctic, we wholeheartedly support and celebrate advancements in the field of cryopreservation. Innovations like the combination of CPAs exemplify the cutting-edge progress that drives our industry forward. While our focus remains on delivering state-of-the-art cryogenic systems and unmatched services, we understand the critical importance of these developments for the future of cellular preservation. Our commitment is to ensure that every sample stored using our technologies has the highest possible chance of survival, helping to preserve the invaluable potential of biological materials for years to come.
By offering advanced, reliable, and precise cryogenic solutions, Consarctic is proud to contribute to the success and reliability of cryopreservation efforts worldwide. Together, we strive for a future where every cryopreserved cell, tissue, or organ can be revitalized to its full potential.